7" SPE Columns with Fine Filter (15–45 µm), Polystyrene, Natural — 200/Bag (208-3378-050)
These 7-inch polystyrene solid-phase extraction columns feature an integrated fine-filter disk rated at 15–45 microns, delivering the highest filtrate clarity in the Caplugs® Evergreen column line for demanding LC-MS/MS injection preparation, confirmatory GC-MS cleanup, and dissolution testing workflows. The 7-inch body provides maximum sorbent bed volume for preparative-scale SPE, high-volume environmental sampling, and complex-matrix extractions where a shorter column bed is insufficient for the required retention or wash-step separation. Supplied non-sterile in bags of 200, part number 208-3378-050 is well suited to high-throughput QC and research laboratories that process large sample loads routinely.
Technical Specifications
| Specification | Value |
|---|---|
| Part Number (MPN) | 208-3378-050 |
| Body Length | 7" |
| Filter Grade | Fine (15–45 microns) |
| Material | Polystyrene (PS) |
| Color | Natural |
| Sterility | Non-Sterile |
| Pack Size | 200/Bag |
| BPA / Phthalate | BPA-Free, Phthalate-Free |
| Country of Origin | USA |
Applications
- Preparative-scale SPE requiring maximum sorbent bed volume and high filtrate clarity
- High-volume environmental water sampling (1–5 L sample loads) with SPE cleanup prior to GC-MS or LC-MS analysis
- Soil and sediment extract cleanup for GC-MS and LC-MS confirmatory methods
- LC-MS/MS injection preparation where residual particulates cause analytical column fouling or injection carryover at low detection limits
- Confirmatory GC-MS cleanup of complex biological and environmental matrices
- Food and agricultural residue QC — pesticide, mycotoxin, and veterinary drug preparation at preparative scale
- Pharmaceutical preparative SPE for fraction collection and scale-up from mini-column methods
- High-volume plasma and urine extract fractionation in bioanalytical and research settings
- Dissolution testing sample preparation where particulate-free filtrate is required
Compatibility
The 7-inch column body is sized to fit standard large-format SPE manifold configurations, including 20-port and 24-port tube-format vacuum manifolds where the longer body occupies a standard large tube position. It is equally compatible with gravity-flow bench stands designed for 7-inch columns. Laboratories scaling up established 5-inch SPE methods will find the 7-inch bed provides a direct volume scale-up path without changes to solvent chemistry or manifold platform. For applications requiring coarser filtration in the same 7-inch format, sibling products 208-3376-050 (Coarse, 90–135 µm) and 208-3377-050 (Medium, 45–90 µm) are available from the same Caplugs® Evergreen column line.
Chemical Resistance
| Reagent / Condition | Compatibility |
|---|---|
| Aqueous buffers / saline | Excellent |
| Dilute acids and bases | Good for routine SPE conditions |
| Methanol (up to ~50%) | Good — suitable for typical SPE conditioning and wash steps |
| Acetone | Not recommended |
| Chlorinated solvents (chloroform, DCM) | Not recommended |
| Aromatic solvents (toluene, hexane) | Not recommended |
| Ethanol (>70%) | Not recommended |
| Autoclave / heat sterilization | Not suitable — PS is not autoclavable |
Quality & Procurement
Made in USA, these columns are manufactured under ISO 9001 quality management from FDA-compliant, BPA-free, phthalate-free polystyrene resin. The integrated filter disk is molded directly into the column body rather than bonded, eliminating adhesive extractables at the frit interface — a critical advantage for sensitive LC-MS, GC-MS, and enzyme-based detection workflows. LabSupplies.com is an authorized dealer of Caplugs® Evergreen consumables and ships from USA inventory, typically the same business day for stocking items, with volume pricing available for institutional purchasers and grant-funded laboratories.
Frequently Asked Questions
What makes the fine (15–45 µm) filter grade the right choice for LC-MS/MS prep?
The 15–45 µm pore rating delivers the highest filtrate clarity in the column line, removing fine particulates that would otherwise cause analytical column fouling, increased back-pressure, or injection carryover at the trace detection limits typical of LC-MS/MS and GC-MS confirmation methods. Coarser filter grades pass more solids and are better suited to gravity-flow screening workflows where downstream sensitivity requirements are less stringent.
Is the filter disk bonded into the column, and could adhesive extractables affect my results?
No adhesive is used. The filter disk is molded directly into the polystyrene column body, eliminating the adhesive-extractable interference at the frit interface that can compromise sensitive LC-MS or enzyme-based assays when bonded frits are used.
Will these columns fit my existing SPE manifold?
The 7-inch body is designed for large-format SPE manifolds, including standard 20-port and 24-port tube-format vacuum manifolds and gravity-flow stands configured for 7-inch columns. If your current manifold is sized for 5-inch columns, the 7-inch body will not seat correctly — verify your manifold's tube-position dimensions before ordering.
Are there other filter grades available in this same 7-inch polystyrene format?
Yes. The Caplugs® Evergreen line includes two sibling products: 208-3376-050 (Coarse filter, 90–135 µm) and 208-3377-050 (Medium filter, 45–90 µm), both in the same 7-inch PS natural format at 200/Bag. Select the coarser grades for higher-flow gravity screening applications where filtrate clarity is less critical.