8219–03 L Microplates, PP, Natural — 290-8219-03L | 15/Box | Caplugs® Evergreen

384-Well Microplate Lids, Polypropylene (PP), Natural — 290-8219-03L | 15/Box (105/Case)

Technical Narrative

The Caplugs® Evergreen is a 384-well Polypropylene (PP) microplate lid — the evaporation control solution for the small-volume 384-well format where edge-well evaporation is a more significant assay integrity risk than in 96-well format. The 20–120 µL working volume range of 384-well wells means a 5–10% evaporation event (which is acceptable in 96-well format) represents a 10–20 µL absolute volume loss per well — a concentration change that is assay-significant in HTS dose-response and enzyme kinetics applications. The PP lid maintains the humid microenvironment around each well to minimize this differential evaporation during incubation. Natural transparent PP allows visual monitoring of plate contents through the lid without removal.

PP construction provides the key performance advantages over the PS lid (290-8218-01L) for demanding 384-well applications: broader DMSO tolerance (≤30% vs ≤10%) for compound library plate coverage, and better autoclave cycle durability for labs sterilizing lids before use in cell-based 384-well assays. At identical price to the PS lid, PP is the economically rational choice when DMSO compound plates or sterilization requirements are part of the workflow.

At $77.67 per Box of 15 — $0.7398 per lid — the delivers 384-well lid coverage at per-lid economics for high-throughput programs. Also available: 290-8218-01L (PS natural).

Technical Specifications — Caplugs® Evergreen

384-Well Lid Workflow Compatibility — PP

The PP 384-well lid reduces evaporation from small-volume 384-well wells during incubation and storage. PP provides broader DMSO tolerance and autoclave durability vs the PS variant:

384-well wells hold only 20–120 µL — evaporation from edge wells is proportionally greater than in 96-well format. For extended incubations (>1 hour at 37°C), consider using EZ-Seal™ film (290-8200-MIC) for tighter sealing than a lid provides.

Chemical Resistance — Polypropylene (PP)

PP provides broader DMSO tolerance and autoclave durability versus the PS lid — the preferred choice for compound plates and repeat-sterilization workflows.

Laboratory Applications

The serves pharmaceutical HTS programs covering 384-well compound treatment plates during incubation; cell-based 384-well assay programs requiring covered incubation in CO2 incubators; ELISA and enzyme assay programs reducing edge-well evaporation during 384-well incubation; and any 384-well workflow requiring evaporation control without hermetic sealing.

U.S. Manufacturing, Quality & Institutional Procurement

Every Caplugs® Evergreen lot is manufactured at our California facility and subject to rigorous quality inspection and material purity verification. We supply reference laboratories, hospital systems, biotech firms, and federal procurement offices under institutional pricing programs with blanket-order support and same-day shipping on stocked inventory. Request a sample below to validate before committing to volume.

Frequently Asked Questions — Caplugs® Evergreen

What is the difference between the PP lid and a plate seal film for 384-well plates?

A lid (like the ) sits loosely on the plate — it reduces evaporation and blocks contamination while allowing gas exchange. An adhesive film seal (EZ-Seal™ 290-8200-MIC) bonds to the plate flange — providing hermetic sealing for PCR thermocycling, long-term storage, and brief centrifugation. For incubation periods under 2–4 hours at 37°C, a lid provides adequate evaporation control. For overnight incubation, PCR, or storage >24 hours, an adhesive film seal provides better protection against the differential edge-well evaporation that causes concentration artifacts in 384-well format.

What is the difference between the PP lid and the PS lid for 384-well plates?

Both fit the same SBS-standard 384-well footprint at the same price. PP provides broader DMSO tolerance (≤30% vs PS ≤10%), better autoclave cycle durability, and broader organic solvent resistance. PS (290-8218-01L) provides slightly higher optical clarity. For compound library plates and repeated sterilization, choose PP. For standard aqueous ELISA and luminescence incubation, either material is equivalent.

Are the lids BPA-free?

Yes. The is molded from virgin Polypropylene (PP) containing no BPA and no phthalate plasticizers.